Dust Generator

acc. to Wright (1950)

The computer-controlled CULTEX® DG – Dust Generator is based on the dust feeder according to Wright (1950) and is recommended as essential peripheral equipment for the exposure of cells to dry powder aerosols.

In combination with the CULTEX® RFS and the CULTEX® Hydraulic Press, the CULTEX® DG completes the optimal setup for in vitro exposure to particles. The included elutriator enables the user to control the size of the delivered particles to under 10 µm.

Especially designed for in vitro exposure systems, the CULTEX® DG is able to provide uniform airborne concentrations of dust for long periods of time.

General features

Generates dry powder aerosols
Uniform airborne concentration
High stability over hours
Selectable feed rate (from 0.24 mm/h to 20.19 mm/h)
Selectable rotation speed (0–800 turns/h)
Computer controlled
All components made from inert material
Easy handling
Easy cleaning
Specially designed reservoir to remove larger particles
Requires press (e.g. CULTEX® HyP · Hydraulic Press)

Application areas

Dry powders (up to 9.8 μm particle size)

Clients

Universities
Public health institutions
Military
Pharmaceutical and chemical industry
Contract research laboratories

System information

Modular design

Aerosol generator top
Substance container
Elutriator
Computer with control software

Basic requirements

2 x Power supply
Compressed air supply (3 bar, 5–20 L/min)

Generation type

Dust feeder according to Wright (1950)
Dry powder aerosol from compressed material
Compressed substance is scraped off with a rotating plate

December 5, 2013
Chemico-Biological Interactions 2013; 206:479-490

“Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility”

Authors:
D. Steinritz, N. Möhle, C. Pohl, M. Papritz, B. Stenger, A. Schmidt, C. J. Kirkpatrick, H. Thiermann, R. Vogel, S. Hoffmann, M. Aufderheide
May 14, 2013
IVTIP 2013, Southhampton

„Prevalidation of the CULTEX® method (BMBF project 0315710): The air-liquid interface exposure of human lung cells in the CULTEX® Radial Flow System (RFS)”

Authors:
N. Möhle, D. Steinritz, C. Pohl, S. Hoffmann, M. Aufderheide

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September 1, 2011
Eurotox 2011, Paris

„Prevalidation of the CULTEX® method: in vitro analysis of the acute toxicity of inhalable fine dusts and nanoparticles after direct exposure of cultivated human cells from the respiratory tract”

Authors:
C. Pohl, N. Möhle, M. Papritz, D. Steinritz, U. Mohr, S. Hoffmann, C.J. Kirkpatrick, M. Aufderheide

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August 1, 2011
In vitro World Congress 2011, Montreal

„Pre-validation of the CULTEX® system assessing the acute inhalation toxicity of nanoparticles by direct exposure of cells via the air-liquid interface”

Authors:
S. Hoffmann, N. Möhle, M. Papritz, C. Pohl, M. Aufderheide

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