Dust Generator

acc. to Wright (1950)

The computer-controlled CULTEX® DG – Dust Generator is based on the dust feeder according to Wright (1950) and is recommended as essential peripheral equipment for the exposure of cells to dry powder aerosols.

In combination with the CULTEX® RFS and the CULTEX® Hydraulic Press, the CULTEX® DG completes the optimal setup for in vitro exposure to particles. The included elutriator enables the user to control the size of the delivered particles to under 10 µm.

Especially designed for in vitro exposure systems, the CULTEX® DG is able to provide uniform airborne concentrations of dust for long periods of time.CULTEX® DG

General features

  • Generates dry powder aerosols
  • Uniform airborne concentration
  • High stability over hours
  • Selectable feed rate (from 0.24 mm/h to 20.19 mm/h)
  • Selectable rotation speed (0–800 turns/h)
  • Computer controlled
  • All components made from inert material
  • Easy handling
  • Easy cleaning
  • Specially designed reservoir to remove larger particles
  • Requires press (e.g. CULTEX® HyP · Hydraulic Press)

Application areas

  • Dry powders (up to 9.8 μm particle size)

Clients

  • Universities
  • Public health institutions
  • Military
  • Pharmaceutical and chemical industry
  • Contract research laboratories

System information

Modular design

  • Aerosol generator top
  • Substance container
  • Elutriator
  • Computer with control software

Basic requirements

  • 2 x Power supply
  • Compressed air supply (3 bar, 5–20 L/min)

Generation type

  • Dust feeder according to Wright (1950)
  • Dry powder aerosol from compressed material
  • Compressed substance is scraped off with a rotating plate
  • December 5, 2013

    Chemico-Biological Interactions 2013; 206:479-490

    “Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility”

    Authors:
    D. Steinritz, N. Möhle, C. Pohl, M. Papritz, B. Stenger, A. Schmidt, C. J. Kirkpatrick, H. Thiermann, R. Vogel, S. Hoffmann, M. Aufderheide

  • May 14, 2013

    IVTIP 2013, Southhampton

    „Prevalidation of the CULTEX® method (BMBF project 0315710): The air-liquid interface exposure of human lung cells in the CULTEX® Radial Flow System (RFS)”

    Authors:
    N. Möhle, D. Steinritz, C. Pohl, S. Hoffmann, M. Aufderheide

    Download poster

  • September 1, 2011

    Eurotox 2011, Paris

    „Prevalidation of the CULTEX® method: in vitro analysis of the acute toxicity of inhalable fine dusts and nanoparticles after direct exposure of cultivated human cells from the respiratory tract”

    Authors:
    C. Pohl, N. Möhle, M. Papritz, D. Steinritz, U. Mohr, S. Hoffmann, C.J. Kirkpatrick, M. Aufderheide

    Download poster

  • August 1, 2011

    In vitro World Congress 2011, Montreal

    „Pre-validation of the CULTEX® system assessing the acute inhalation toxicity of nanoparticles by direct exposure of cells via the air-liquid interface”

    Authors:
    S. Hoffmann, N. Möhle, M. Papritz, C. Pohl, M. Aufderheide

    Download poster

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